Publications (last four years)

• 2020

N6-Adenosine Methylation of miRNA-200b-3p Influences Its Functionality and Is a Theranostic Tool.
Briand J, Sérandour AA, Nadaradjane A, Bougras-Cartron G, Heymann D, Ory B, Vallette FM, Cartron PF.
Mol Ther Nucleic Acids. 2020 Aug 14;22:72-83.

Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme.
Cheray M, Etcheverry A, Jacques C, Pacaud R, Bougras-Cartron G, Aubry M, Denoual F, Peterlongo P, Nadaradjane A, Briand J, Akcha F, Heymann D, Vallette FM, Mosser J, Ory B, Cartron PF. Mol Cancer. 2020 Feb 25;19(1):36.
Radiotherapy-induced overexpression of exosomal miRNA-378a-3p in cancer cells limits natural killer cells cytotoxicity.
Briand J, Garnier D, Nadaradjane A, Clément-Colmou K, Potiron V, Supiot S, Bougras-Cartron G, Frenel JS, Heymann D, Vallette FM, Cartron PF. Epigenomics. 2020 Mar;12(5):397-408. doi: 10.2217/epi-2019-0193. Epub 2020 Apr 8. PMID: 32267172

The hydroxymethylome of multiple myeloma identifies FAM72D as a 1q21 marker linked to proliferation.

Chatonnet F, Pignarre A, Sérandour AA, Caron G, Avner S, Robert N, Kassambara A, Laurent A, Bizot M, Agirre X, Prosper F, Martin-Subero JI, Moreaux J, Fest T, Salbert G.

Haematologica. 2020 Mar;105(3):774-783. doi: 10.3324/haematol.2019.222133. Epub 2019 Jun 20. PMID: 31221779

Cell-free circulating epimarks in cancer monitoring.

Duforestel M, Briand J, Bougras-Cartron G, Heymann D, Frenel JS, Vallette FM, Cartron PF. 

Epigenomics. 2020 Jan;12(2):145-155. doi: 10.2217/epi-2019-0170. Epub 2020 Jan 9. PubMed PMID:31916450.

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Epigenetic protein complexes: the adequate candidates for the use of a new generation of epidrugs in personalized and precision medicine in cancer

Cartron PF, Cheray M, Bretaudeau L.

Epigenomics. 2020 Jan;12(2):171-177. doi:10.2217/epi-2019-0169. Epub 2019 Dec 18. PubMed PMID: 31849240.

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Identification of a transient state during the acquisition of temozolomide resistance in glioblastoma.

Rabé M, Dumont S, Álvarez-Arenas A, Janati H, Belmonte-Beitia J, Calvo GF,
Thibault-Carpentier C, Séry Q, Chauvin C, Joalland N, Briand F, Blandin S, Scotet E, Pecqueur C, Clairambault J, Oliver L, Perez-Garcia V, Nadaradjane A, Cartron PF, Gratas C, Vallette FM.  Cell Death Dis. 2020 Jan 6;11(1):19. doi:1038/s41419-019-2200-2. PubMed PMID: 31907355; PubMed Central
PMCID: PMC6944699.

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• 2019

Diuron exposure and Akt overexpression promote glioma formation through DNA hypomethylation

Briand J, Nadaradjane A, Bougras-Cartron G, Olivier C, Vallette FM, Cartron PF.

Clin Epigenetics. 2019 Nov 14;11(1):159. doi: 10.1186/s13148-019-0759-1.

PMID: 31727122 Free PMC Article

Diuron modulates the DNA methylation status of the ILT7 and TRAIL/TNFSF10 genes and decreases the killing activity of plasmacytoid dendritic cells
Josephine Briand, Marie-Pierre Joalland, Arulraj Nadaradjane, Gwenola Bougras-Cartron, Christophe Olivier, François Vallette, Sylvain Perruche, Pierre-Francois Cartron
Environmental Sciences Europe, 2019, 31 (1), ⟨10.1186/s12302-019-0219-8⟩

Glyphosate Primes Mammary Cells for Tumorigenesis by Reprogramming the Epigenome in a TET3-Dependent Manner.

Duforestel M, Nadaradjane A, Bougras-Cartron G, Briand J, Olivier C, Frenel JS, Vallette FM, Lelièvre SA, Cartron PF.

Front Genet. 2019 Sep 27;10:885. doi: 10.3389/fgene.2019.00885. eCollection 2019.

PMID: 31611907

Epigenetic Metalloenzymes.

Blanquart C, Linot C, Cartron PF, Tomaselli D, Mai A, Bertrand P.

Curr Med Chem. 2019;26(15):2748-2785. doi: 10.2174/0929867325666180706105903. Review.

PMID:29984644

Characterization of circulating tumor cells as a reflection of the tumor heterogeneity: myth or reality?

Brown HK, Tellez-Gabriel M, Cartron PF, Vallette FM, Heymann MF, Heymann D.

Drug Discov Today. 2019 Mar;24(3):763-772. doi: 10.1016/j.drudis.2018.11.017. Epub 2018 Nov 26. Review.

PMID 30496853

Dormant, quiescent, tolerant and persister cells: Four synonyms for the same target in cancer.

Vallette FM, Olivier C, Lézot F, Oliver L, Cochonneau D, Lalier L, Cartron PF, Heymann D.

Biochem Pharmacol. 2019 Apr;162:169-176. doi: 10.1016/j.bcp.2018.11.004. Epub 2018 Nov 9. Review.

PMID:30414937

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• 2018

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TRPS1 regulates oestrogen receptor binding and histone acetylation at enhancers.

Serandour AA, Mohammed H, Miremadi A, Mulder KW, Carroll JS.

Oncogene. 2018 Sep;37(39):5281-5291. doi: 10.1038/s41388-018-0312-2. Epub 2018 Jun 12.

PMID: 29895970

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Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogene c-KIT and amplifies cell proliferation.

Debaize L, Jakobczyk H, Avner S, Gaudichon J, Rio AG, Sérandour AA, Dorsheimer L, Chalmel F, Carroll JS, Zörnig M, Rieger MA, Delalande O, Salbert G, Galibert MD, Gandemer V, Troadec MB.

Nucleic Acids Res. 2018 Nov 30;46(21):11214-11228. doi: 10.1093/nar/gky756

PMID:30500954

Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma.

Hervouet E, Peixoto P, Delage-Mourroux R, Boyer-Guittaut M, Cartron PF.

Clin Epigenetics. 2018 Feb 9;10:17. doi: 10.1186/s13148-018-0450-y. eCollection 2018. Review.

PMID:29449903

miR-370-3p Is a Therapeutic Tool in Anti-glioblastoma Therapy but Is Not an Intratumoral or Cell-free Circulating Biomarker.

Nadaradjane A, Briand J, Bougras-Cartron G, Disdero V, Vallette FM, Frenel JS, Cartron PF.

Mol Ther Nucleic Acids. 2018 Dec 7;13:642-650. doi: 10.1016/j.omtn.2018.09.007. Epub 2018 Sep 13.

PMID:30497054

Loss of miR-198 and -206 during primary tumor progression enables metastatic dissemination in human osteosarcoma.

Georges S, Calleja LR, Jacques C, Lavaud M, Moukengue B, Lecanda F, Quillard T, Gabriel MT, Cartron PF, Baud'huin M, Lamoureux F, Heymann D, Ory B.

Oncotarget. 2018 Nov 6;9(87):35726-35741. doi: 10.18632/oncotarget.26284. eCollection 2018 Nov 6.

PMID:30515265

PD-L1 expression is regulated by both DNA methylation and NF-kB during EMT signaling in non-small cell lung carcinoma.

Asgarova A, Asgarov K, Godet Y, Peixoto P, Nadaradjane A, Boyer-Guittaut M, Galaine J, Guenat D, Mougey V, Perrard J, Pallandre JR, Bouard A, Balland J, Tirole C, Adotevi O, Hendrick E, Herfs M, Cartron PF, Borg C, Hervouet E.

Oncoimmunology. 2018 Feb 1;7(5):e1423170. doi: 10.1080/2162402X.2017.1423170. eCollection 2018.

PMID:29721376

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• 2017

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Alterations in DNA methylation/demethylation intermediates predict clinical outcome in chronic lymphocytic leukemia.

Bagacean C, Tempescul A, Le Dantec C, Bordron A, Mohr A, Saad H, Olivier V, Zdrenghea M, Cristea V, Cartron PF, Douet-Guilbert N, Berthou C, Renaudineau Y.

Oncotarget. 2017 Aug 9;8(39):65699-65716. doi: 10.18632/oncotarget.20081. eCollection 2017 Sep 12.

PMID:29029465

The phosphorylation of Metaxin 1 controls Bak activation during TNFα induced cell death.

Petit E, Cartron PF, Oliver L, Vallette FM.

Cell Signal. 2017 Jan;30:171-178. doi: 10.1016/j.cellsig.2016.11.008. Epub 2016 Nov 12.

PMID:27845183

ERRα induces H3K9 demethylation by LSD1 to promote cell invasion.

Carnesecchi J, Forcet C, Zhang L, Tribollet V, Barenton B, Boudra R, Cerutti C, Billas IM, Sérandour AA, Carroll JS, Beaudoin C, Vanacker JM.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3909-3914. doi: 10.1073/pnas.1614664114. Epub 2017 Mar 27.

PMID:28348226

Cytosine modifications modulate the chromatin architecture of transcriptional enhancers.

Mahé EA, Madigou T, Sérandour AA, Bizot M, Avner S, Chalmel F, Palierne G, Métivier R, Salbert G.

Genome Res. 2017 Jun;27(6):947-958. doi: 10.1101/gr.211466.116. Epub 2017 Apr 10.

PMID:28396520

5-hydroxymethylcytosine marks postmitotic neural cells in the adult and developing vertebrate central nervous system.

Diotel N, Mérot Y, Coumailleau P, Gueguen MM, Sérandour AA, Salbert G, Kah O.

J Comp Neurol. 2017 Feb 15;525(3):478-497. doi: 10.1002/cne.24077. Epub 2016 Jul 29.

PMID:27414756

The logic of transcriptional regulator recruitment architecture at cis-regulatory modules controlling liver functions.

Dubois-Chevalier J, Dubois V, Dehondt H, Mazrooei P, Mazuy C, Sérandour AA, Gheeraert C, Guillaume P, Baugé E, Derudas B, Hennuyer N, Paumelle R, Marot G, Carroll JS, Lupien M, Staels B, Lefebvre P, Eeckhoute J.

Genome Res. 2017 Jun;27(6):985-996. doi: 10.1101/gr.217075.116. Epub 2017 Apr 11.

PMID:28400425

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